Using a murine model of immunisation and challenge with
LCMV, we demonstrated robust virologic protection with these
Discussion and/or Conclusion(s):
These data provide an important
insight into the nature of adenoviral vector vaccination, and the
potential for minimal epitope-insert adenovector vaccines. This is
particularly of relevance in the setting of current novel adenoviral
vaccines against pathogens such as Ebola, Malaria and RSV.
Hepatitis B vaccination in HIVoutpatients
are the updated British
HIVAssociation guidelines being adhered to?
, Monica Desai
, Charles Lacey
YorSexual Health and York University
Hepatitis B (HBV) vaccination is safe and well tolerated
in HIV positive patients and significantly reduces risk of both new and
chronic infection. National vaccination guidelines were updated in
November 2015 recommending several changes to vaccination
practice such as the dose of vaccine given, number of vaccines per
schedule and time to assess response to vaccination. Few studies of
adherence to vaccination guidelines exist and we know of none which
relate to the updated guidelines.
To evaluate adherence to the updated BHIVA
Hepatitis B vaccination guidelines within an HIV outpatient services.
A retrospective case note review auditing HBV vaccination
practice in patients attending HIV out-patient clinic at Yorsexual
Health between December 2015
156 patients attended clinic within the audit period. 90% of
patients were screened within a month of HIV diagnosis and 83% had
HBV infection and immunity screened for within the last year. The
majority of the cohort were HBV immune (81%) and of the non
immune 55% were vaccine naive. All vaccine naive patients were
offered primary vaccination with a 92% uptake. However vaccination
practice had several flaws themost common being incorrect number of
doses per primary schedule.
Discussion and/or Conclusion(s):
There are several gaps in vaccin-
ation practice when compared to national guidelines. Although
primary vaccination is offered according to BHIVA guidelines,
updated recommendations such as dose of vaccine and most notably
number of vaccines in vaccination schedule are not being met. In
addition non-responders to primary vaccination are not being
Attitudes of healthcare staff influencing the uptake of influenza
, Eleanor Mc Namara
Cherry Orchard Hospital, Health
Service Executive (HSE),
Consultant Microbiologist Cherry Orchard
Hospital, Health Service Executive
Irish and international guidelines recommend annual
influenza vaccination of all healthcare workers(HCWs) to protect
themselves and to reduce the risk of transmission from HCWs to
patients. However, vaccine uptake among HCWs is below the national
To identify the attitudes and beliefs of HCWs towards influenza
vaccine and their influence on vaccine uptake.
Study Design: A qualitative retrospective systematic review.
Electronic data sources reviewed: These included CINAHL, Medline,
Embase, Cochrane Library, PsycINFO and PubMed (2000
search was performed using defined MeSH terms and keywords.
Studies related to influenza vaccination on patients were excluded.
Filtering of 289 studies resulted in 18 studies that fulfilled the
study criteria. 4 descriptive themes for declining vaccination emerged
(a) Misconceptions about influenza vaccine, (b) Fear of adverse
reactions, (c) Doubts about vaccine efficacy and (d) Perceived
minimal personal health risk from influenza. These were balanced
by 4 descriptive themes for accepting the vaccine, which were (a)
Personal benefit (b) Patient benefit (c) Protect the HCW
s family and
(d) Professional responsibility as a HCW.
From these 8 descriptive themes, four key analytical themes emerged.
Two were negative based on (1) Issues with the vaccine and (2) HCWs
perception on personal health risk. However two were positive based
on (1) the benefits of vaccination and (2) the role of a HCW.
Influenza vaccine uptake by HCWs is influenced by
complex factors. Identification of these beliefs and attitudes could be
used to impact positively on future influenza vaccine campaign for
Varicella immunisation in healthcare workers in a large London
Ons El Hayet Ben Ismail, Tabitha Mahungu, Joan Adeniji, Dianne Irish.
Royal Free NHS Trust
Varicella (chickenpox) is an acute, highly infectious
disease caused by the varicella zoster virus (VZV).
In 2003, the Department of Health (DoH) recommended that non-
immune healthcare workers (HCWs) should receive varicella vaccine.
HCWs with a negative or uncertain history of chickenpox or shingles
should be serologically tested and a full course of VZV vaccine offered
only to those without VZV antibody.
To determine the uptake of VZV vaccination in
HCWs in a large London teaching hospital.
A retrospective review of all the HCWs tested for VZV IgG
between 01/01/2011 to 31/012/2015 was performed.
3456/3630 (95%) HCWs tested for VZV IgG antibody were
positive. 152/3630 (4%) were negative and 22/3630 (1%) were
75/174 (43%) of the susceptible HCWs received 2 doses of VZV
vaccination. 20/174 (11%) received only one dose and 79/174 (45%) did
not receive any doses.
Data from the 58/99 susceptible HCWs who did not receive the full
course show: 6 had health reasons, 16 declined and 36 had left the
Of the non-immune HCWs, demographic data was available for
140/174: 60/140 (43%) were allied health professionals, 45/140 (32%)
were nurses, 24/140 (17%) were doctors and 11/140 (8%) were
Discussion and/or Conclusion(s):
Ongoing education of healthcare
workers by Occupational Health departments and increased aware-
ness of the importance of varicella vaccination are necessary for
improved uptake by health care workers.
Seroprevalence of pertussis, diphtheria and poliovirus antibodies
among healthcare personnel in Singapore
Helen Oh, Subbiah Dnamodaran.
Changi General Hospital
Immunization against diphtheria, poliomyelitis and per-
tussis was initiated in 1938, 1958 and 1959 respectively in Singapore.
The aim of the study was to examine the pre-
valence of pertussis, diphtheria and poliovirus antibodies in health-
care personnel in Changi General Hospital.
Annual health screening of healthcare personnel in Changi
General Hospital was conducted in September 2014. Residual sera
from health care personnel were collected. Human IgG antibodies
against Bordetella pertussis, diphtheria toxoid and poliovirus (all
3 serotypes simultaneously) were measured using enzyme-linked
A total of 352 healthcare personnel were recruited; 150
healthcare personnel in 21
30 age group, 150 in 31
40 age groups and
52 personnel in above 40 age group.
The seroprevalence of antibodies against all 3 serotype of poliovirus
was 68.47% (95% CI 63.4
73.1%). It decreased significantly with age
from94% in 21
30 age group, 60% in 31
40 age group and 19.23% above
Abstracts of FIS/HIS 2016
Poster Presentations / Journal of Hospital Infection 94S1 (2016) S24