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Page Background

logistics, patient perception and a lack of local expert clinical advice.

The frozen FMT service was designed to overcome these issues and

provide an accessible, timely, widespread service.


The aims of the service evaluation are to describe

the demographics of FMT patients, establish whether the clinical

outcomes are comparable to those described in the literature, evaluate


acceptance of FMT and determine if an FMT bank can provide

a regional service.


The service has been evaluated using clinical outcomes,

patient satisfaction surveys, and quality of life (QoL) surveys. Data is

collected pre-procedure, immediately post-procedure, at 6 week and 6



Fifteen patients were treated in the first 6 months of

operation. Preliminary data shows the demographics of patient

receiving FMT are similar to those with chronic CDI (mean age 69,

Charlson comorbidity index 4 M:F ratio 1:1). Outcomes are similar to

those reported in the literature; 80% of patients resolving symptoms

following first FMT. Patient feedback is positive; QoL has increased

significantly (Mean: 20 point increase). Information and the procedure

have an average rating >4/5. FMT uptake in Wessex; All regional

hospitals perform FMTs locally.

Discussion and/or Conclusion(s):

The service is achieving promising

clinical and QoL outcomes, patients are positive about FMTs and the

uptake shows a regional bank is a desirable resource.

ID: 4861

PPI exposure and carriage of multi-resistant Gram negative


Lewis Jones


, Richard Cunningham


, Doyo Enki


, Robert Tischhauser






Plymouth University Peninsula Schools of Medicine and Dentistry


Gram-negative bacterial resistance is a major cause of

infection, which is usually preceded by ingestion and colonization of

the gastrointestinal tract. Proton Pump Inhibitor (PPI) use is a proven

risk factor for infectionwith gastrointestinal pathogens. We carried out

a case-control study to determine whether PPI use is also associated

with an increased carriage rate of multi-resistant Gram negative



To determine whether prior use of PPIs is a risk

factor for diagnosis of multi-resistant Gram-negative infection

compared with a matched control group with no infection or infection

with a sensitive organism.


A retrospective case note review of Plymouth Hospital

inpatients between 1/4/14 and 31/3/15 was performed. 130 patients

with ESBL producing E. coli or K. pneumoniae (cases) were identified

and compared with 130 controls without identified resistance.

Controls were matched by age, gender, admission date, source

(hospital, nursing home, home) and admitting Care Group (Medical,

Surgical, Women & Children).


Preliminary results after analyzing the first 78 patients

suggest that the proportion of cases taking PPI is higher than in the

control group. 21 of 40 cases and 13 of 38 controls were taking a PPI on

or during the 6 months before admission. Full results and statistical

analysis after inclusion of all subjects will be presented.

Discussion and/or Conclusion(s):

Preliminary results suggest a

positive association between carriage of ESBL producing Gram-

negative bacteria, and PPI use. If confirmed in a larger sample, PPI

stewardship may be an additional control measure to reduce

transmission of resistant Gram negative bacteria.

ID: 4984

10 year case review of bacteraemias due to



in a UK tertiary hospital

Huina Yang


, Luke Bedford


, Charlotte Summers


, Sani Aliyu



David Enoch




Cambridge University Hospitals NHS Foundation Trust,


Papworth Hospital NHS Foundation Trust,


University of Cambridge



Mycobacterium abscessus

complex are a group of

rapidly growing, multidrug-resistant non-tuberculous mycobacteria.

They are associated with a wide range of clinical syndromes in both

immunocompetent and immunosuppressed individuals.

M. abscessus

are successful pathogens due to their ability to form biofilms which

aids environmental survival and easy colonisation of mucosal surfaces

and invasive devices.


We reviewed the medical notes and laboratory data of all

patients with

Mycobacterium abscessus

bacteraemia over a 10 year

period. Five patients were identified over this period. All 5 patients

had at least one central intravascular device at the time of the

bacteraemia. Four out of 5 were health-care associated. Four of the

patients were also post transplantation. The time to positivity of

the blood culture bottles ranged from 5 to 10 days. The majority

(4 out of 5) had multiple sets of blood cultures with

M. abscessus


In our series, the 30 day mortality was 20% and 90 day mortality

was 40%.

Discussion and/or Conclusion(s):

In our experience,

M. abscessus

frequently causes an indolent infection associated with intravascu-

lar devices. Increased morbidity is associated with subsequent

seeding to distant sites, particularly in imunocompromised indivi-

duals. Although the diagnosis is often delayed, the increase use of

new diagnostics in the routine laboratory, such as MALDI-TOF has

helped to improve early identification and treatment.

M. abscessus

should be regarded as a true pathogen when identified in blood

cultures, and prompt removal of suspected infected intravascular

catheters may be essential for the successful management of this


Topic: Decontamination

ID: 4687

Use of wipes for patient hand hygiene

Christina Bradley


, MartynWilkinson


, Adam Fraise


, Martin Kiernan




Hospital Infection Research Laboratory, Queen Elizabeth Hospital



Hospital Infection Research Laboratory, Queen

Elizabeth Hospital Birmingham,


Visiting Clinical Fellow, University

of West London


Much attention has focussed on hand decontamination

for healthcare workers; little attention has been paid to patient hand

hygiene. Patients confined to bed are often unable to access hand

washing facilities. They could use an alcohol hand rub but these are not

advised for soiled hands or social hand hygiene. One alternative is the

use of a hand wipe, similar to those supplied by airlines and

restaurants. However, is this an effective way of removing transient

micro-organisms from the hands? This study was designed to assess

the efficacy of an antimicrobial hand wipe (Clinell



Handwipe) compared with hand washing.


The methodology was based on EN 1499 (2013) and EN

1500 (2013) as there is no standard for this type of product. The hands

of 20 volunteers were artificially contaminated by immersion in

Escherichia coli

and then sampled before and after using a reference

soft soap or a wipe with and without an antimicrobial agent for 60

seconds. The counts obtained were expressed as log


and the log


reductions calculated.


The patient hand wipe with no antimicrobial agent was

inferior to the soft soap. However, the antimicrobial wipe was

statistically non-inferior to the soft soap. A log


reduction of 3.54

was obtained for the reference, 2.46 for the control patient wipe, and

3.67 for the antimicrobial patient wipe.

Discussion and/or Conclusion(s):

The evidence suggests that the

antimicrobial patient wipe, when applied for 60 seconds, is at least as

good as soap and water, representing an acceptable alternative to

handwashing from a bactericidal perspective.

Abstracts of FIS/HIS 2016

Oral Presentations / Journal of Hospital Infection 94S1 (2016) S11