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Investigation of existing and novel antimicrobial agents to

treat intravascular catheter-related infections caused by

Staphylococcus aureus

Eoghan O


Department of Clinical Microbiology, RCSI, Dublin 9, and

Department of Microbiology, Connolly Hospital, Dublin 15, Ireland

Infection of intravascular catheters by

Staphylococcus aureus

is a

significant risk factor within the healthcare setting. To treat these

infections and attempt salvage of an intravascular catheter, catheter

lock solutions (CLSs) are being increasingly used. However, the most

effective CLSs against these biofilm mediated infections has yet to

be determined and clinical practice varies greatly. The purpose of

this study was to (1) evaluate and compare the efficacy of

antibiotics and antiseptics in current clinical use against biofilms

produced by reference and clinical isolates of

S. aureus

, (2) evaluate

the efficacy and suitability of two newly described antimicrobial

agents, ML:8 (containing caprylic acid) and Citrox (containing

falvonoids), as CLSs versus

S. aureus

biofilms grown

in vitro




and (3) evaluate the effectiveness of a number of enzymatic

agents to disrupt

S. aureus

biofilm by developing static and flow

biofilm assays to represent an


like model of infection.

Findings from these studies report the true therapeutic potential of

existing and novel agents in the treatment of

S. aureus


related biofilm infections.

Abstracts of FIS/HIS 2016

HIS Grants Abstracts / Journal of Hospital Infection 94S1 (2016) S22