28 / 150
Investigation of existing and novel antimicrobial agents to
treat intravascular catheter-related infections caused by
Staphylococcus aureus
Eoghan O
’
Neill.
Department of Clinical Microbiology, RCSI, Dublin 9, and
Department of Microbiology, Connolly Hospital, Dublin 15, Ireland
Infection of intravascular catheters by
Staphylococcus aureus
is a
significant risk factor within the healthcare setting. To treat these
infections and attempt salvage of an intravascular catheter, catheter
lock solutions (CLSs) are being increasingly used. However, the most
effective CLSs against these biofilm mediated infections has yet to
be determined and clinical practice varies greatly. The purpose of
this study was to (1) evaluate and compare the efficacy of
antibiotics and antiseptics in current clinical use against biofilms
produced by reference and clinical isolates of
S. aureus
, (2) evaluate
the efficacy and suitability of two newly described antimicrobial
agents, ML:8 (containing caprylic acid) and Citrox (containing
falvonoids), as CLSs versus
S. aureus
biofilms grown
in vitro
and
in
vivo
and (3) evaluate the effectiveness of a number of enzymatic
agents to disrupt
S. aureus
biofilm by developing static and flow
biofilm assays to represent an
in-vivo
like model of infection.
Findings from these studies report the true therapeutic potential of
existing and novel agents in the treatment of
S. aureus
catheter-
related biofilm infections.
Abstracts of FIS/HIS 2016
–
HIS Grants Abstracts / Journal of Hospital Infection 94S1 (2016) S22
–
S23
S23